Identification et prévalences des SIVs chez les primates non-humains sauvages afin d'estimer les risques de nouvelles transmissions inter-espèces et d'étudier plus en détails les réservoirs des ancêtres du HIV-1 chez les grands singes en Afrique Centrale.
Contexte et Objectifs
Our studies will provide better knowledge on:
- SIVcpz and SIVgor diversity as well as whether group M and N ancestors are restricted to chimpanzees and group O ancestors to gorillas,
- whether group M ancestors are restricted to the extreme south-east of Cameroon or if such variants are also present in ape populations in neighboring regions, especially in Gabon,
- whether chimpanzees harboring SIVgor like viruses infected gorillas and humans independently; or whether chimpanzees harboring SIVgor like viruses infect only gorillas, who then passed the virus on to humans,
- whether bonobos and mountain gorillas are infected with SIV,
- estimate risk for potential new cross-species transmission with SIVs from primate bushmeat
- whether SIV cross-species transmissions have actually been missed, and whether new SIVs will be found in the context of HIV-1 group M infections because of the potential for recombination with circulating HIV-1 strains
- whether SIV infections have a negative impact on health and survival of great apes.